<i><scp>MYC</scp></i> status determination in aggressive <scp>B</scp>‐cell lymphoma: the impact of <scp>FISH</scp> probe selection

Abstract

Taking into account the prognostic and therapeutic implications of the MYC translocation, probe design and limitations should be particularly kept in mind when MYC hybridization patterns are interpreted. In our experience, detection of 8q24 abnormalities could be optimized by a two-probe approach involving the application of both IGH-MYC dual-fusion and MYC break-apart selected kits.