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Roles of Cellular Respiration, Cg <i>CDR1</i> , and Cg <i>CDR2</i> in <i>Candida glabrata</i> Resistance to Histatin 5

Eva J. Helmerhorst, Caterina Venuleo, Dominique Sanglard, Frank G. Oppenheim

Antimicrobial Agents and Chemotherapy · 2006 · 20 citations · 21 references

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Abstract

Histatin 5, a human salivary protein with broad-spectrum antifungal activity, is remarkably ineffective against Candida glabrata. Fluconazole resistance in this fungus is due in most cases to upregulation of CgCDR efflux pumps. We investigated whether the distinct resistance of C. glabrata to histatin 5 is related to similar mechanisms.

References

21

Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.

Frank G. Oppenheim, Tao Xu, F M McMillian et al. · Journal of Biological Chemistry · 1988 · 647 citations · Full text

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The ATP Binding Cassette Transporter Gene <i>CgCDR1</i> from <i>Candida glabrata</i> Is Involved in the Resistance of Clinical Isolates to Azole Antifungal Agents

Dominique Sanglard, Françoise Ischer, David Calabrese et al. · Antimicrobial Agents and Chemotherapy · 1999 · 342 citations · Full text

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Human β-Defensins 2 and 3 Demonstrate Strain-Selective Activity against Oral Microorganisms

Sophie Joly, Connie A. Maze, Paul B. McCray et al. · Journal of Clinical Microbiology · 2004 · 291 citations · Full text

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Azole Resistance in <i>Candida glabrata</i> : Coordinate Upregulation of Multidrug Transporters and Evidence for a Pdr1-Like Transcription Factor

John‐Paul Vermitsky, Thomas D. Edlind · Antimicrobial Agents and Chemotherapy · 2004 · 283 citations · Full text

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Role of ATP-Binding-Cassette Transporter Genes in High-Frequency Acquisition of Resistance to Azole Antifungals in <i>Candida glabrata</i>

Dominique Sanglard, Françoise Ischer, Jacques Billé · Antimicrobial Agents and Chemotherapy · 2001 · 253 citations · Full text

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