Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload

Abstract

The ECM genes were the most altered during reverse remodelling. There was a change in isoform constitution as collagen type I increased transiently at 3 days followed by a later increase in types III and VIII at 7 days after DB. This might be important for the biomechanical properties of the heart and recovery of cardiac function.