Inhibition of Grade Dependent Autophagy in Urothelial Carcinoma Increases Cell Death under Nutritional Limiting Condition and Potentiates the Cytotoxicity of Chemotherapeutic Agent

Abstract

Autophagy is related to urothelial carcinoma grade and regulated via the AMPK pathway for tumor cell survival. Autophagy inhibition leads to cancer cell death through an intrinsic apoptotic pathway. The potential application of autophagy inhibitors as an adjunct to chemotherapy for urothelial carcinoma must be explored.