Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Breast Combined with Pharmacokinetic Analysis of Gadolinium-DTPA Uptake in the Diagnosis of Local Recurrence of Early Stage Breast Carcinoma

Abstract

Dynamic scanning proved essential for the detection and differential diagnosis of local tumor recurrence. Pharmacokinetic analysis of Gd-DTPA uptake can be used to produce parametric images that retain the spatial resolution of the original images while providing additional information about lesion permeability and vascularity, and helping to avoid the observer variability associated with ROI analysis.