Gold‐Catalyzed Oxidative Cyclization of 1,5‐Enynes Using External Oxidants

Abstract

Golden circle: Two gold-catalyzed oxidative cyclizations of 1,5-enynes using 8-methylquinoline N-oxide are presented (see example). Experimental results indicate that both reactions proceed through prior oxidation of alkyne to form α-carbonyl intermediates and subsequent intramolecular carbocyclization.