Tubulointerstitial nephritis and uveitis (TINU) syndrome: epidemiology, diagnosis and management

Abstract

Acute tubulointerstitial nephritis is demonstrated in 2–3% of all native renal biopsies, increasing to 10–15% if the biopsy is performed in the setting of acute renal failure [1]. It is most commonly related to medication or infection [1,2]. An increasingly recognized entity is tubulointerstitial nephritis with uveitis (TINU) syndrome. We outline the clinical course of a patient with TINU syndrome and review the changes in epidemiology, diagnosis and management.