In vitro effects of dynamic strain on the proliferative and metabolic activity of human osteoblasts.

Abstract

The results demonstrate that cyclic strain at physiologic magnitude leads to an increase of early osteoblast activities related to matrix production while those activities which are characteristic for the differentiated osteoblast and relevant for matrix mineralization are decreased. These new findings confirm in vivo observations about the importance of dynamic strain for bone formation during fracture healing and bone remodeling and could contribute to the optimization of fracture healing.