Local<scp>l</scp>-Arginine Delivery After Balloon Angioplasty Reduces Monocyte Binding and Induces Apoptosis

Abstract

Intramural delivery of L-arginine immediately after angioplasty causes a sustained increase in tissue L-arginine levels associated with enhancement of local NO synthesis. The local increase in NO synthesis is associated with an attenuation of monocyte binding and increased apoptosis of resident macrophages. This treatment strategy could be valuable for the prevention and management of restenosis.