Petasis Three-Component Coupling Reactions of Hydrazides for the Synthesis of Oxadiazolones and Oxazolidinones

Abstract

An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.