Cyclosporin‐Induced Downregulation of the Expression of E‐Cadherin During Proliferation of Edentulous Gingival Epithelium in Rats

Abstract

CsA treatment reduced the production of E-cadherin but increased the production of beta-catenin, Cyclin D1, and PCNA. Thus, CsA may downregulate E-cadherin gene expression, leading to the epithelial cell proliferation of gingival overgrowth.