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A breakdown in macromolecular synthesis preceding differentiation in Streptomyces coelicolor A3(2)
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1990
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Nucleic Acid SynthesisBacteriologyMacromolecular SynthesisBiosynthesisBioenergeticsPhysiological StressNatural Product BiosynthesisMicrobial EcologyEnvironmental MicrobiologyStructure-function Enzyme KineticsTransitory CessationStreptomyces Coelicolor A3Prokaryotic SystemBiochemistryBiocatalysisMolecular MicrobiologyProtein BiosynthesisBiologyNatural SciencesMicrobiologyMedicine
A transitory cessation of growth was recorded in Streptomyces coelicolor A3(2) at the end of vegetative mycelium formation on solid medium. In the same phase a striking reduction in protein and nucleic acid synthesis was detected. Growth and macromolecular synthesis resumed, nearly reaching the original values, when morphological differentiation occurred. It is concluded that a physiological stress occurs within the bacterial population just before the onset of the morphological differentiation.