Synthesis of selenophene derivatives as novel CHK1 inhibitors

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

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Life Sciences, Biochemistry, Molecular Biology +17

The Chk1 Protein Kinase and the Cdc25C Regulatory Pathways Are Targets of the Anticancer Agent UCN-01

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Discovery of 5-[5-Fluoro-2-oxo-1,2- dihydroindol-(3<i>Z</i>)-ylidenemethyl]-2,4- dimethyl-1<i>H</i>-pyrrole-3-carboxylic Acid (2-Diethylaminoethyl)amide, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

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Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Flora Tang et al. · Journal of Medicinal Chemistry · 1998 · 488 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation

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Life Sciences, Cell Biology, Molecular Biology +17