Contrast-enhanced Blood-Pool MR Angiography with Optimized Iron Oxides: Effect of Size and Dose on Vascular Contrast Enhancement in Rabbits

Abstract

The smallest iron oxide provided signal enhancement comparable with that of gadopentetate dimeglumine at 40 micromol iron per kilogram for first-pass investigations, with prolonged signal enhancement up to 25 minutes, allowing multiple measurements after injection of a single bolus.