Journal of Applied Polymer Science · 2003 · 22 citations · 43 references
PharmacyChemical EngineeringPharmaceuticsControlled Release FormulationsDrug DeliveryOral Drug DeliveryDrug Delivery SystemsDrug PermeationMembrane MaterialsPolymer MembranesPolymeric Drug Delivery SystemsPolymeric MembranesBoundary Layer ResistanceDrug Delivery PolymersDrug-loaded MembranesFilm ThicknessMembrane Drug PermeabilityMembrane-controlled ReleasePermeation MechanismPolymer-based Release Systems
Abstract A controlled‐release preparation of diclofenac sodium for transdermal administration has been developed. Poly(vinyl alcohol) (PVA) and PVA/poly(acrylic acid) (PAA) alloy membranes were prepared from a solvent‐casting technique using different PVA/PAA (v/v) ratios. The release of the drug from the membrane was evaluated under in vitro conditions at pH 7.4. The delivery system provided linear release without time lag, burst effect, and boundary layer resistance. Effects of variables such as film thickness and PVA/PAA ratio on the permeation behavior of the polymeric membranes were discussed. The optimal PVA/PAA was determined as 50/50. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 72–77, 2004
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J. W. Westwater, H. G. Drickamer · Journal of the American Chemical Society · 1957 · 4.1K citations
Polymer science and technology
N.L. Hancox · Materials & Design (1980-2015) · 1995 · 430 citations
Natural Sciences, Materials Engineering, Materials Science +12
Pharmacological Properties of Diclofenac Sodium and Its Metabolites
R. Menassé, P. R. Hedwall, J. Kraetz et al. · Scandinavian Journal of Rheumatology · 1978 · 228 citations