Enantioselective Kita Oxidative Spirolactonization Catalyzed by In Situ Generated Chiral Hypervalent Iodine(III) Species

Abstract

The iodines(III) have it: The rational design of a conformationally flexible C2-symmetric iodosylarene catalyst has been used for the enantioselective Kita oxidative spirolactonization. The reaction occurs through secondary n–σ* or hydrogen-bonding interactions between the chiral catalyst and the substrate. Mes=mesityl (2,4,6-trimethylphenyl).