Alveolar cell carcinoma-like antigen and antibodies in patients with alveolar cell carcinoma and other cancers.

Abstract

Antiserum was produced in sheep against a particle pellet recovered from human alveolar cell carcinoma (ACC). The antiserum was used for the detection of similar antigens in patients with ACC using the immunodiffusion method. Tumor cell lines were used in the indirect fluorescent technique for the detection of antibodies in the serum of patients with tumors and control serum. The results indicate that similar antigens are present in the serum of some patients with ACC, primary adenocarcinoma of the lung, and Hodgkin's disease. Antibodies develop in some patients with ACC and primary adenocarcinoma of the lung and in sheep inoculated with the agent.