The dosimetry of⁶⁷Ga citrate in man

Abstract

Estimations have been made of the absorbed dose to various organs in the human body resulting from the intravenous administration of carrier free 67Ga citrate. Observations were made on 19 patients all known to have Hodgkin's disease. Measurements were made of whole-body radioactivity, the activity in blood and, for 11 patients who were undergoing laparotomy, splenectomy, or multiple lymph-node biopsy in tissue specimens. Estimates of the absorbed dose gave values of 0·29, 1·21, 1·87, 1·3 (upper limit) and 0·26 rad/mCi injected to blood, liver, spleen, bone marrow, and whole body respectively. These values were somewhat higher than those reported earlier which were derived from measurements in male August-Marshall hybrid rats.