Clinical manifestations of familial paraganglioma and phaeochromocytomas in <i>succinate dehydrogenase B</i> (<i>SDH‐B</i>) gene mutation carriers

Abstract

SDH-B mutation carriers develop disease early and predominantly in extra-adrenal locations. Disease penetrance is incomplete. Metastatic disease is prominent but levels are less than previously reported. Clinical manifestations may include papillary renal cell carcinoma and macrovascular disease.