Concepedia

Neuregulin/ErbB Signaling Regulates Cardiac Subtype Specification in Differentiating Human Embryonic Stem Cells

Wei-Zhong Zhu, Yiheng Xie, Kara White Moyes, Joseph Gold, Bardia Askari, Michael A. Laflamme

Circulation Research · 2010 · 215 citations · 82 references

DOIFull text

Open access

Abstract

NRG-1β/ErbB signaling regulates the ratio of nodal- to working-type cells in differentiating hESC-CM cultures and presumably functions similarly during early human heart development. We speculate that, by manipulating NRG-1β/ErbB signaling, it will be possible to generate preparations of enriched working-type myocytes for infarct repair, or, conversely, nodal cells for potential use in a biological pacemaker.

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