Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells

Abstract

The FFA-induced loss of IRI is an acute effect independent of the FFA employed. It cannot be sufficiently explained by FFA-induced perturbances of IRI secretion and biosynthesis. We therefore postulate an additional FFA-triggered mechanism, e.g. intracellular IRI degradation.