Concepedia

In Vitro Pharmacodynamics of Anidulafungin and Caspofungin against <i>Candida glabrata</i> Isolates, Including Strains with Decreased Caspofungin Susceptibility

Jason M. Cota, Michael Carden, John R. Graybill, Laura K. Najvar, David S. Burgess, Nathan P. Wiederhold

Antimicrobial Agents and Chemotherapy · 2006 · 40 citations · 28 references

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Abstract

The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC(50) values), and IC(90) values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

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