Concepedia

Posaconazole Mono- or Combination Therapy for Treatment of Murine Zygomycosis

Ashraf S. Ibrahim, Teclegiorgis Gebremariam, Julie Schwartz, John E. Edwards, Brad Spellberg

Antimicrobial Agents and Chemotherapy · 2008 · 106 citations · 13 references

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Concepts

Abstract

We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not improve survival or reduce fungal burden versus placebo.

References

13

Posaconazole Is Effective as Salvage Therapy in Zygomycosis: A Retrospective Summary of 91 Cases

J.-A. H. van Burik, R S Hare, Howard F. Solomon et al. · Clinical Infectious Diseases · 2006 · 614 citations · Full text

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Posaconazole as Salvage Therapy for Zygomycosis

Richard N. Greenberg, Kathleen M. Mullane, J.-A. H. van Burik et al. · Antimicrobial Agents and Chemotherapy · 2005 · 555 citations · Full text

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The iron chelator deferasirox protects mice from mucormycosis through iron starvation

Ashraf S. Ibrahim, Teclegiorgis Gebermariam, Yue Fu et al. · Journal of Clinical Investigation · 2007 · 306 citations · Full text

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Caspofungin Inhibits <i>Rhizopus oryzae</i> 1,3-β- <scp>d</scp> -Glucan Synthase, Lowers Burden in Brain Measured by Quantitative PCR, and Improves Survival at a Low but Not a High Dose during Murine Disseminated Zygomycosis

Ashraf S. Ibrahim, Joel Bowman, Valentina Avanessian et al. · Antimicrobial Agents and Chemotherapy · 2005 · 209 citations · Full text

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Combination Therapy with Amphotericin B Lipid Complex and Caspofungin Acetate of Disseminated Zygomycosis in Diabetic Ketoacidotic Mice

Brad Spellberg, Yue Fu, John E. Edwards et al. · Antimicrobial Agents and Chemotherapy · 2005 · 186 citations · Full text

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