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5-Nitroimidazole Drugs Effective against Metronidazole-Resistant <i>Trichomonas vaginalis</i> and <i>Giardia duodenalis</i>

Jacqueline Upcroft, Linda A. Dunn, Janelle M. Wright, Kamel Benakli, Peter Upcroft, Patrice Vanelle

Antimicrobial Agents and Chemotherapy · 2005 · 127 citations · 10 references

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Abstract

Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.

References

10

Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis

Steven M. Townson, Jacqueline Upcroft, Peter Upcroft · Molecular and Biochemical Parasitology · 1996 · 139 citations

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In Vitro Metronidazole and Tinidazole Activities against Metronidazole- Resistant Strains of <i>Trichomonas vaginalis</i>

Andrea Crowell, Kolby A. Sanders-Lewis, W. Evan Secor · Antimicrobial Agents and Chemotherapy · 2003 · 129 citations · Full text

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Drug Susceptibility Testing of Anaerobic Protozoa

Jacqueline Upcroft, Peter Upcroft · Antimicrobial Agents and Chemotherapy · 2001 · 127 citations · Full text

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<i>Trichomonas vaginalis</i> -Induced Epithelial Monolayer Disruption and Human Immunodeficiency Virus Type 1 (HIV-1) Replication: Implications for the Sexual Transmission of HIV-1

Patricia C. Guenthner, W. Evan Secor, Charlene S. Dezzutti · Infection and Immunity · 2005 · 125 citations · Full text

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Efficacy of New 5-Nitroimidazoles against Metronidazole-Susceptible and -Resistant <i>Giardia</i> , <i>Trichomonas</i> , and <i>Entamoeba</i> spp

Jacqueline Upcroft, R. Wayne Campbell, Kamel Benakli et al. · Antimicrobial Agents and Chemotherapy · 1999 · 118 citations · Full text

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