Concepedia

Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis

Norihiro Kobayashi, Shunichiro Takezaki, Ichiro Kobayashi, Naomi Iwata, Mitsuharu Mori, Kozo Nagai, Naoko Nakano, Masahiro Miyoshi, Nao Kinjo, Takashi Murata,

Lara D. Veeken · 2014 · 140 citations · 33 references

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Abstract

High serum levels of IL-18, KL-6, ferritin and anti-MDA5 antibodies (e.g. >200 units by ELISA) are associated with RP-ILD. These can be used as an indication for early intensive treatment. Both alveolar macrophages and autoimmunity to MDA5 are possibly involved in the development of RP-ILD associated with JDM.

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Takahisa Gono, Shoichiro Sato, Yasushi Kawaguchi et al. · Lara D. Veeken · 2012 · 329 citations · Full text