Facile one-pot synthesis of α-amino phosphonates using lanthanide chloride as catalyst

Abstract

An efficient preparation of α-amino phosphonates by the one-pot condensation of aldehydes, amines, and dialkyl phosphites using catalytic amounts of lanthanide chloride under mild conditions is successfully developed. Moreover, the catalyst is water-tolerant and could be recovered and reused. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:389–392, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20219