Chemoenzymatic Syntheses of ω‐Ureido <scp>D</scp>‐Amino Acids

Abstract

D-Amino acids can be prepared chemoenzymatically in very high yields with high enantioselectivity by cleavage of the corresponding hydantoins with Agrobacterium radiobacter bacterial culture. Hydantoins with highly functionalized side chains are also accepted. The synthetic concept is discussed taking D-citrulline (1) as example.