JNCI Journal of the National Cancer Institute · 1977 · 47 citations · 0 references
Life SciencesCell BiologyOncologyHematologic OncologyMolecular VirologyVirologyB Cell BiologyHematologic MalignanciesLymphocyte DevelopmentLymphoid NeoplasmsAcute Lymphoblastic Leukemia BiologyB-cell Acute Lymphoblastic LeukemiaB-cell LeukemiaEpstein-barr Virus - Associated MalignanciesSurface Features
A human B-cell line designated as BALL-1 was established from the peripheral blood of a patient with acute lymphoblastic leukemia (ALL). Neither Epstein-Barr virus (EBV) particles nor EBV-determined nuclear antigen (EBNA) was detectable. The morphologic and growth characteristics were clearly distinct from those of numerous EBV-positive lymphoblastoid cell lines previously reported. BALL-1 cells probably originated from the donor's leukemia cells as judged from their cytogenetic, morphologic, and surface features. The BALL-1 line was the first EBNA-negative B-cell line established from ALL.