Comparison of Clinical and Microbiological Response to Treatment of<i>Clostridium difficile</i>–Associated Disease with Metronidazole and Vancomycin

Abstract

In an observational study with a limited number of subjects, a majority of patients with C. difficile-associated disease responded to therapy with metronidazole or vancomycin. Failure with metronidazole treatment may be attributable to a slower and less consistent microbiological response than that with oral vancomycin treatment.