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2,3‐Disubstituted Indoles through the Palladium‐Catalyzed Reaction of Aryl Chlorides with <i>o</i>‐Alkynyltrifluoroacetanilides
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2006
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Chemical EngineeringCross-coupling ReactionAryl ChloridesEngineeringPalladium‐catalyzed ReactionExcellent YieldsDiversity-oriented SynthesisNatural SciencesFluorous SynthesisOrganic ChemistryPd 2Organometallic CatalysisCatalysisChemistrySynthetic Chemistry
Abstract 2,3‐Disubstituted indoles can be prepared in moderate to excellent yields by reacting readily available o ‐alkynyltrifluoroacetanilides with aryl chlorides in MeCN at 120 °C in the presence of Pd 2 (dba) 3 and Xphos.