R Factors from Proteus morganii

Abstract

SUMMARY: Twenty-eight R factors transmissible to Escherichia coli K12 were derived from 178 naturally occurring strains of Proteus morganii and evidence was found of non-transmissible resistance plasmids in some strains. Nine plasmids were assigned to group N; one P. morganii strain carried two N plasmids which were incompatible in reference strains of E. coli or P. morganii. Six fi + R factors of group FII were found. One was unique among F-like plasmids in conferring hspII restriction. Entry exclusion by these R factors had a specificity distinct from that of FII plasmids previously described. Three R factors of compatibility group FI were the first recognized plasmids of this group with repressed pilus synthesis. Two fi + R factors incompatible with R6K (and with this plasmid constituting group X) were identified, as were one plasmid of group P and an R factor compatible with plasmids of all groups so far described and therefore assigned to a new group (M). Similarities and differences between the R factor sets of P. morganii and P. rettgeri are discussed.