Rhodium(III)‐Catalyzed Direct C‐2 Olefination of Unactivated Indoles Utilizing OH/NH₂ as Directing Group

Abstract

Abstract Oxidative C‐2 olefination of indoles/pyrrole via rhodium(III)‐catalyzed direct CH bond activation is reported. Phenolic OH and aniline NH 2 units were revealed to be effective chelating groups to activate the aryl CH bond. The reactions proceeded with excellent selectivity and high functional group tolerance, furnishing 2‐vinylindoles/2‐vinylpyrroles in good yields. magnified image