Concepedia

Synthesis of 2,4-diaza-4-deoxypodophyllotoxin, a new analogue of podophyllotoxin possessing antitumour activity

Yukio Hitotsuyanagi, Yoichi Naka, Keiji Yamagami, Akihiro Fujii, Tetsuya Tahara

Journal of the Chemical Society Chemical Communications · 1995 · 19 citations · 14 references

DOI

Concepts

Abstract

2,4-Diaza-4-deoxypodophyllotoxin 4 and its cis analogue 14 are synthesised stereoselectively from 3,4-methylenedioxyaniline 5, and show significant activity against vincristine-resistant P-388 leukaemia in vivo.

References

14

Aminohaloborane in organic synthesis. 1. Specific ortho substitution reaction of anilines

Tsutomu Sugasawa, Tatsuo Toyoda, Makoto Adachi et al. · Journal of the American Chemical Society · 1978 · 144 citations

, , +6

The semiempirical derivation of <sup>13</sup>C nuclear magnetic resonance chemical shifts. Hydrocarbons, alcohols, amines, ketones, and olefins

Helmut Beierbeck, John K. Saunders, John W. ApSimon · Canadian Journal of Chemistry · 1977 · 128 citations · Full text

, , +14

Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin.

François Leteurtre, J. Madalengoitia, Ann Orr et al. · PubMed · 1992 · 72 citations

, , +13

Design, synthesis, and antitumor activity-absolute configuration relationships of podophyllotoxin aza-analogues

Kiyoshi Tomioka, Yoshihiro Kubota, Kenji Koga · Tetrahedron · 1993 · 53 citations

, , +14

Synthesis of caseadine methyl ether

Michael P. Cava, M. V. Lakshmikantham, Michael J. Mitchell · The Journal of Organic Chemistry · 1969 · 46 citations

, , +6