A Redox‐Activated MRI Contrast Agent that Switches Between Paramagnetic and Diamagnetic States

Abstract

Trigger ready: A redox-activated MRI contrast agent can cycle between paramagnetic CoII (MRI-active) and diamagnetic CoIII (MRI-silent). The paramagnetic CoII form produces a highly shifted CEST signal at 135 ppm (37 °C). The redox state of the Co complex is altered by O2 partial pressure and reductant concentration (thiols) on a time scale relevant to imaging. MT=magnetization transfer. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.