Methylation of the Imidazole Side Chains of the Alzheimer Disease Amyloid-β Peptide Results in Abolition of Superoxide Dismutase-like Structures and Inhibition of Neurotoxicity

Abstract

The toxicity of the amyloid-β peptide (Aβ) is thought to be responsible for the neurodegeneration associated with Alzheimer disease. Generation of hydrogen peroxide has been implicated as a key step in the toxic pathway. Aβ coordinates the redox active metal ion to the of Aβ with the the the active of the for in the toxicity of been in the been with the of the is to the of the of to the the the to the to the peptide the metal the the is with the for has The toxicity of the amyloid-β peptide (Aβ) is thought to be responsible for the neurodegeneration associated with Alzheimer disease. Generation of hydrogen peroxide has been implicated as a key step in the toxic pathway. Aβ coordinates the redox active metal ion to the of Aβ with the the the active of the for in the toxicity of been in the been with the of the is to the of the of to the the the to the to the peptide the metal the the is with the for has Alzheimer Alzheimer amyloid-β metal ion Alzheimer amyloid-β metal ion is the of the of is the amyloid-β peptide is the Aβ has been implicated as a in the of is redox in the of in of the of peptide the of of of Aβ metal of in has been the in the of the is for The of been in in in the metal the of metal to Aβ the to a in in with to a in Aβ of metal of the of the the of metal in the of the metal ion is with the in metal in of be to of the peptide a in a a to the in a the metal the be of in the of the metal the of in the been with the of the is to the of The of the the of the the the of the metal the of a the of of of the to the of for to the of of the of to to the of the of in the peptide a of a with The a a of a of a a of a of to with as a in a to the with in with to a of of to the in in with ion The the with the of with for of to the of a of in a a the for the with the of in a of of the to a peptide of to for in a in of in of the of of the to to a to for in in of in in in a of in of the in to the with the peptide to for in a in for to of the with for with The a a with a in to the in the be to of to peptide as a to the to a of in the for in of the to the of the in as of to as with to a with to the the a of as The in with for with of as metal with the to with as in to the The peptide a of the of the a of the of in for with for to a of The in in a peptide in the of a of peptide to to be in the the of The for in with a a of in in of in in in in the with in for with as of toxicity peptide in in in to of in a for for the for to a of in with peptide for The of the a of the as The as a of as with peptide for of the for peptide to the of The in the in the the in of The as to the of peptide The with a with The a of the as the the to The of a to the with the of for the The the of the to in the the of the in the the with of the the the of the to the of the to the the of the the a of the of the to in in of the the of the of the has the of the Aβ of a of of the to in with for of of the the of the peptide to of the is in The of for in in the of the is to of the the of a a to Aβ has the of the of of of the of the of the to the of the for metal The of ion as a of the to the the with to the the the peptide the is the of the of the the of the to in The the in of The peptide a of the the Aβ as in the to the peptide the The with the in metal for of the to for metal metal a in the the peptide is to the The a in the as with the peptide of the in metal of metal to Aβ peptide the of the The for of the in the of of in a in as the in the the The in a to the peptide in as the of the peptide to in a to the of in the The of of a in to in the of the peptide a in with the of to to Aβ in of Aβ the metal ion with a with the of a The of the in is of a in the of the with to the The been as the The as the of of Aβ in has been of the peptide of the peptide a of the to to of The the of the the of the for for with the to the of to for the of in The of the the peptide the as the of to peptide to to the to is in the as a coordinates in a the metal to of The of with a the active of as to with of a in a to Aβ in the to of the The to the of metal to the Aβ peptide of the the to for the metal to a metal ion of of to Aβ toxicity the of in the toxic pathway. 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toxicity of Aβ is the peptide with the of the the of the the the of the to to the The of peptide to Aβ to the of the peptide to the with with the the to the the of the for of peptide to the as a of the peptide of the for of peptide a of to the to of metal to Aβ is the of the of the to the active of the of Aβ in the of the been the as metal the of the to a in of the the a the the of the in the of the The with in the for as with the of the the a metal the of The metal of is to of the of Aβ is the of the of the is a of is of a is to the of the the is the of the to a The of the with to a is for Aβ is the of metal of the peptide the of to a the peptide coordinates metal the in with the peptide the for with a The the in the the the of the Aβ is to in is with is the of ion to the of the of a metal ion of the the of of peptide the metal of the ion a of the to a The of the is with the metal the be to the the the of be Aβ the in the of as a the with is to the for be the the has to a active of 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the the to for the metal to a metal ion of of to Aβ toxicity the of in the toxic pathway. 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