Enantioselective, Thiourea‐Catalyzed Intermolecular Addition of Indoles to Cyclic <i>N</i>‐Acyl Iminium Ions

Abstract

Fair game for indoles, N-acyl iminium ion intermediates underwent intermolecular addition by these nucleophiles under the catalysis of a chiral thiourea Schiff base derivative. A variety of functionalized indole frameworks were assembled with high enantioselectivity from simple precursors by this method (see scheme; TMS=trimethylsilyl; R=H, Me, vinyl, OMe, F, Cl, Br; R1=benzyl, methyl; n=1,2). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.