Two‐Way Nanopore Sensing of Sequence‐Specific Oligonucleotides and Small‐Molecule Targets in Complex Matrices Using Integrated DNA Supersandwich Structures

Abstract

Pore me another one: Sub-nanomolar sequence-specific DNA detection and sub-micromolar small-molecule (ATP) detection was shown by way of self-assembly and disassembly of DNA superstructures within solid-state nanopores (see scheme). These DNA structures provide a built-in amplification mechanism to increase the signal strength and sensitivity. This sensor was also shown to work within complex mixtures, such as mammalian serum. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.