Concise Access to a Model of the Marine Alkaloid Halicyclamine A through Macrocycle‐Forming Addition of a 5‐Aminopenta‐2,4‐dienal onto a 2,3‐Dihydropyridinium Salt

Abstract

A biomimetic synthesis of a model compound for the marine alkaloid halicyclamine A is reported that involves a macrocyclization through the intramolecular addition of a 5-aminopenta-2,4-dienal onto a 2,3-dihydropyridinium salt generated in situ (see scheme). In this way, a monomacrocyclic model, with the same relative stereochemistry as that of the natural product, was obtained. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.