Outcome of four patients with chronic myeloid leukemia after imatinib mesylate discontinuation

Abstract

cells/mL, 50 times more than in patients withmetastatic cancer without bone marrow involvement.This may be the consequence of various not mutuallyexclusive mechanisms, including: (i) a stromal alteration,evidenced in these patients by a frequent dry tap bonemarrow aspiration and some degree of fibrosis;