2‐Lithio‐1‐phenylpyrrole: X‐Ray Structure Analysis and ⁶Li‐¹H 2D Heteronuclear Overhauser NMR Spectroscopy (2D HOESY)

Abstract

By activation of H atoms in close spatial proximity, the Li substituent of a monolithium compound influences the position of the second lithiation. The crystal structure and the cross signals in the 6Li1H 2D HOESY spectrum of 1 revealed three short LiH separations. Indeed, the H atom with the smallest separation (H11) is replaced upon reaction with nBuLi.