Concepedia

Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction

Sudeep Pushpakom, Neill J. Liptrott, Sonia Rodríguez‐Nóvoa, Pablo Labarga, Vincent Soriano, Marta Albalater, Elizabeth Hopper-Borge, Stefano Bonora, Giovanni Di Perri, David Back,

The Journal of Infectious Diseases · 2011 · 107 citations · 31 references

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Abstract

TFV is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence TFV renal tubular transport and contribute to the development of KTD. These results need to be replicated in other cohorts.

References

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David Verhelst, Matthieu Monge, Jean‐Luc Meynard et al. · American Journal of Kidney Diseases · 2002 · 354 citations

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Mechanism of Active Renal Tubular Efflux of Tenofovir

Adrian S. Ray, Tomáš Cihlář, Kelly L. Robinson et al. · Antimicrobial Agents and Chemotherapy · 2006 · 324 citations · Full text