Selective ET _A Receptor Antagonism Reduces Neointimal Hyperplasia in a Porcine Coronary Stent Model

Abstract

Oral, selective ET(A) receptor antagonism significantly reduced neointimal hyperplasia forming over porcine coronary stented injuries in the first 28 days. This strategy may have clinical potential for the limitation and treatment of coronary restenosis after percutaneous revascularization.