Rational Design of a Fluorescence‐Turn‐On Sensor Array for Phosphates in Blood Serum

Abstract

Getting turned on: An order-of-magnitude fluorescence amplification of simple tripodal sensors has been observed in the presence of phosphate ions. An X-ray structure analysis of one of the complexes (see picture) shows the binding of three phosphate ions, which closely resembles the anionic part of ATP, by the sensor. The sensors were used to generate cross-reactive arrays that can detect anions in human serum.