Pharmacokinetics and Metabolism of Glyceryl Guaiacolate in Ponies

Abstract

SUMMARY Kinetics of disappearance of glyceryl guaiacolate from plasma and the metabolic fate following intravenous administration were studied in 10 ponies. Complete muscle relaxation, with the exception of the diaphragm, was observed in ponies with plasma concentrations of glyceryl guaiacolate in excess of 238 μg./ml. A pronounced sex difference in the duration of action was observed, with the stallions requiring a longer period to recover. This difference was attributable to a slower rate of disappearance of the drug from the plasma in male ponies. The only urinary metabolites isolated were catechol and polar metabolites which were probably conjugates of catechol. Untoward effects were not observed in any pony with the dosages employed in this investigation.