Clinical Infectious Diseases · 2002 · 353 citations · 24 references
MedicineOrthopedic SurgerySurgeryInfection PreventionOrthopedicsPerioperative Infection PreventionAntibiotic ProphylaxisHealthcare-associated Infection PreventionOrthopedic Infection PreventionPostoperative Infection PreventionSurgical ProphylaxisSurgical Site InfectionInfection Prevention After SurgeryOrthopedic Surgical Infection PreventionPerioperative Antibiotic UsePlacebo-controlled Efficacy AssessmentRelative Risk EstimationRelative Risk ReductionSurgical Site Infection ProphylaxisSurgical Site Infection Reduction
The study aimed to assess whether perioperative mupirocin nasal ointment eradicates Staphylococcus aureus carriage and reduces surgical site infections in orthopedic surgery. In a randomized, double‑blind, placebo‑controlled trial, 614 patients received mupirocin or placebo ointment twice daily from admission until surgery, with 315 assigned to mupirocin and 299 to placebo. Mupirocin markedly eradicated nasal carriage (83.5% vs 27.8%) and lowered endogenous S.
The objective of this study was to determine whether use of mupirocin nasal ointment for perioperative eradication of Staphylococcus aureus nasal carriage is effective in preventing the development of surgical site infections (SSIs). A randomized, double-blind, placebo-controlled design was used. Either mupirocin or placebo nasal ointment was applied twice daily to 614 assessable patients from the day of admission to the hospital until the day of surgery. A total of 315 and 299 patients were randomized to receive mupirocin and placebo, respectively. Eradication of nasal carriage was significantly more effective in the mupirocin group (eradication rate, 83.5% versus 27.8%). In the mupirocin group, the rate of endogenous S. aureus infections was 5 times lower than in the placebo group (0.3% and 1.7%, respectively; relative risk, 0.19; 95% confidence interval, 0.02–1.62). Mupirocin nasal ointment did not reduce the SSI rate (by S. aureus) or the duration of hospital stay
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Guideline for Prevention of Surgical Site Infection, 1999
Alicia J. Mangram, Teresa Horan, Michele L. Pearson et al. · Infection Control and Hospital Epidemiology · 1999 · 4.6K citations
Medicine, Microbiology, Surgery +17