Glucosamine‐6‐sulfamate Analogues of Heparan Sulfate as Inhibitors of Endosulfatases

Abstract

Keeping sulfate: The extracellular endosulfatases, which modulate signaling pathways by removing sulfate groups from heparan sulfate can be inhibited by replacing the 6-sulfate destined for cleavage with an inhibitory sulfamate motif. Glucosamine-6-sulfamate analogues demonstrate biochemical inhibition and utility as tools to understand the biological and therapeutic relevance of the endosulfatases. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.