Lewis Acid Activated Aza‐Diels–Alder Reaction of <i>N</i>‐(3‐Pyridyl)aldimines: An Experimental and Computational Study

Abstract

Abstract A combined theoretical and experimental study of a Povarov‐type cycloaddition reaction suggests an asynchronous concerted process that is favored by double Lewis acid activation with BF 3 · Et 2 O; endo selectivity was observed in the reactions between N ‐(3‐pyridyl)aldimines and styrene, cyclopentadiene, or indene, and substituted tetrahydro‐1,5‐naphthyridine derivatives were obtained in a regio‐ and stereoselective fashion.