Publication | Open Access
Triphenylphosphine promoted addition of acetylenic esters to benzofuran-2,3-dione: One-pot synthesis of novel γ-spirolactones
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2008
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EngineeringHeterocyclicNatural SciencesDiversity-oriented SynthesisOne-pot SynthesisOrganic ChemistrySynthetic ChemistryChemistryZwitterionic IntermediatesGood YieldPharmacologyHeterocycle ChemistryOne-pot RouteNovel γ-SpirolactonesAcetylenic EstersBiomolecular EngineeringNatural Product Synthesis
The reaction of the zwitterionic intermediates generated from dialkyl acetylene dicarboxylates and triphenylphosphine with benzofuran-2,3-diones provides a one-pot route to new highly functionalized γ-spirolactones in good yield.