Domino Reaction of 2,3‐Epoxy‐1‐alcohols and PIFA in the Presence of H₂O and the Concise Synthesis of (+)‐Tanikolide

Abstract

Lactols are prepared by a single operation, in which 2,3-epoxy-1-alcohols are treated with phenyliodine(III) bis(trifluoroacetate) (PIFA) in the presence of H2O. Thus, an efficient domino three- or four-step sequence has been developed and applied to the concise synthesis of (+)-tanikolide (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z501686_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.