Simple Synthesis of 1‐Amino‐1‐cyclopropanecarboxylic Acids from <i>tert</i>‐Butyl Isocyanoacetate and Epoxides; Synthesis of Alkyl 5,6‐Dihydro‐4<i>H</i>‐1,3‐oxazine‐4‐carboxylates

Abstract

A new approach to the synthesis of the biologically active 1-amino-1-cyclopropanecarboxylic acids 2 is characterized, among other things, by inexpensive starting materials and the convenient double hydrolysis of 1 to give 2.